Nucleophilic additions to thionolactones. New synthetic technology for the construction of medium and large ring ethers

KC Nicolaou, DG McGarry, PK Somers…

Index: Nicolaou, K. C.; McGarry, D. G.; Somers, P. K.; Veale, C. A.; Furst, G. T. Journal of the American Chemical Society, 1987 , vol. 109, # 8 p. 2504 - 2506

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Citation Number: 74

Abstract

Medium-and large-ring molecular frameworks are abundant in nature'and are increasingly becoming targets for total synthesis. While a plethora of methods are now available for the synthesis of medium lactones and macrolactones, technology for the construction of the corresponding cyclic ethers is still emerging2 In this paper we report a new method for the construction of medium and large cyclic ethers from the readily available lactones3 via the ...