Fluorinated 9H-xanthene-9-carboxylic acid oxazol-2-yl-amides as potent, orally available mGlu1 receptor enhancers

…, S Jolidon, F Knoflach, V Mutel, J Wichmann

Index: Vieira, Eric; Huwyler, Joerg; Jolidon, Synese; Knoflach, Frederic; Mutel, Vincent; Wichmann, Juergen Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 6 p. 1666 - 1669

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Citation Number: 29

Abstract

Small molecule mGluR1 enhancers, which are 9H-xanthene-9-carboxylic acid [1, 2, 4] oxadiazol-3-yl-and (2H-tetrazol-5-yl)-amides, have been previously reported. Fluorinated 9H- xanthene-9-carboxylic acid oxazol-2-yl-amides with improved pharmacokinetic properties have been designed and synthesized as useful pharmacological tools for the study of the physiological roles mediated by mGlu1 receptors. The synthesis and the structure–activity ...