An efficient synthesis for eslicarbazepine acetate, oxcarbazepine, and carbamazepine

…, MM Mohan, K Srinivas, AP Reddy, R Bandichhor

Index: Ravinder; Rajeshwar Reddy; Sridhar; Murali Mohan; Srinivas, Katkam; Panasa Reddy; Bandichhor, Rakeshwar Tetrahedron Letters, 2013 , vol. 54, # 22 p. 2841 - 2844

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Citation Number: 4

Abstract

Efficient methods have been developed for the synthesis of three active pharmaceutical ingredients (APIs) carbamazepine (Tegretol®) 1, oxcarbazepine (Trileptal®) 2, and eslicarbazepine acetate (Exalief®) 3 by employing enantioselective reduction and carboxamidation reaction.