Organic letters

Copper-Catalyzed Aliphatic C–H Amination with an Amidine Moiety

H Chen, S Sanjaya, YF Wang, S Chiba

Index: Chen, Hui; Sanjaya, Stephen; Wang, Yi-Feng; Chiba, Shunsuke Organic Letters, 2013 , vol. 15, # 1 p. 212 - 215

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Citation Number: 43

Abstract

A method for amination of aliphatic C–H bonds of N-alkylamidines is described that utilizes Cu (OAc) 2 as the catalyst in the presence of PhI (OAc) 2 and K3PO4. The resulting products, dihydroimidazoles and tetrahydropyrimidines, could be converted into the corresponding diamines by hydride reduction.