Synthesis and antifungal activity of 2/3-arylthio-and 2, 3-bis (arylthio)-5-hydroxy-/5-methoxy-1, 4-naphthoquinones
…, JY Shim, MJ Chae, IH Choi, JY Han, OJ Jung…
Index: Ryu, Chung-Kyu; Shim, Ju-Yeon; Mi, Jin Chae; Ik, Hwa Choi; Han, Ja-Young; Jung, Ok-Jai; Jung, Yoon Lee; Seong, Hee Jeong European Journal of Medicinal Chemistry, 2005 , vol. 40, # 5 p. 438 - 444
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Citation Number: 41
Abstract
2/3-Arylthio-and 2, 3-bis (arylthio)-5-hydroxy-/5-methoxy-1, 4-naphthoquinones 5–9 were synthesized and tested for in vitro antifungal activity against Candida species and Aspergillus niger. The synthesized compounds 5–9 generally showed good activities against Candida albicans and C. tropicalis. The results suggest that the 1, 4- naphthoquinones 5–9 would be potent antifungal agents.
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