A Lewis Acid Palladium (II)-Catalyzed Three-Component Synthesis of α-Substituted Amides
T Beisel, G Manolikakes
Index: Beisel, Tamara; Manolikakes, Georg Organic Letters, 2013 , vol. 15, # 23 p. 6046 - 6049
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Citation Number: 19
Abstract
Herein we want to report a new, more general “amide” version of the Petasis reaction using a cooperative dual catalyst system capable of combining nucleophilic and electrophilic activation.(10) Our initial idea was to generate the reactive acyl imine in situ via an acid-mediated condensation between an amide and an aldehyde(11) and to use a suitable transition metal to activate simple commercial available arylboronic acids for addition to the formed ...
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