Solvatochromic Reagents for Multicomponent Reactions and their Utility in the Development of Cell??Permeable Macrocyclic Peptide Vectors

BH Rotstein, R Mourtada, SO Kelley…

Index: Rotstein, Benjamin H.; Mourtada, Rida; Kelley, Shana O.; Yudin, Andrei K. Chemistry - A European Journal, 2011 , vol. 17, # 44 p. 12257 - 12261

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Citation Number: 25

Abstract

Peptides that are composed of proteinogenic amino acids have the capacity to engage in native interactions with protein targets, but usually lack the ability to effectively translocate membrane barriers.[1] Synthetic peptides have found numerous in cellulo applications, most commonly as fluorescent imaging agents and as activity-based probes.[2–4] The biochemical properties displayed by peptides would make them ideal scaffolds in the ...