Oriental Journal of Chemistry

Synthesis and Hydrolysis Kinetic Study of Few Co-drugs of Propranolol and other Antihypertensive Drugs

M Baidya, A Kumar Das

Index: Baidya, Mayukh; Das, Amit Kumar Oriental Journal of Chemistry, 2011 , vol. 27, # 1 p. 173 - 178

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Citation Number: 1

Abstract

ABSTRACT The different acyl halide analogs of propranolol were synthesized by reacting Propanolol with different acyl anhydrides in toluene medium. The derivatives were reacted with thionyl chloride to get propranolol hemi acyl chloride. Finally the co-drugs were synthesized by reacting propranolol hemi acyl chloride with different classes of antihypertensive drugs like Nifedepine (PSN, PMN, PPN), Hydrochlorthiazide (PSH, PMH, ...