Transformation of chlorofluoroethyldiethylamines to N, N-diethyldifluoroacetamide

F Liška, F Hampl, V Dědek

Index: Liska, Frantisek; Hampl, Frantisek; Dedek, Vaclav Collection of Czechoslovak Chemical Communications, 1980 , vol. 45, # 3 p. 740 - 745

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Abstract

Abstract Hydrolysis of 2-chloro-1, 1, 2-trifluoroethyldiethylamine (I) and 2, 2-dichloro-1, 1- difluoroethyl-diethylamine (II) in the presence of triethylamine afforded N, N- diethylchlorofluoroacetamide (VII) and NN-diethyldichloroacetamide (VIII), respectively. Triethylamine hydrofluoride, arising in the reaction, was used for fluorination and transformation of the amides VII and VIII to N, N-diethyldifluoroacetamide (VI). The C-Cl ...