Rapid access to cis-cyclobutane γ-amino acids in enantiomerically pure form
V André, A Vidal, J Ollivier, S Robin, DJ Aitken
Index: Andre, Virginie; Vidal, Anne; Ollivier, Jean; Robin, Sylvie; Aitken, David J. Tetrahedron Letters, 2011 , vol. 52, # 12 p. 1253 - 1255
Full Text: HTML
Citation Number: 14
Abstract
The (+)-(1R, 2S) and (−)-(1S, 2R) stereoisomers of 2-(aminomethyl) cyclobutane-1- carboxylic acid have been prepared using a short and efficient strategy, which employs the photochemical [2+ 2] cycloaddition reaction between ethylene and an unsaturated γ-lactam as the key step.
Related Articles:
An efficient scalable process for the synthesis of N-Boc-2-tert-butyldimethylsiloxypyrrole
[Tian, Zhenping; Rasmussen, Michael; Wittenberger, Steven J. Organic Process Research and Development, 2002 , vol. 6, # 4 p. 416 - 418]