General methodology for cis-hydroisoquinoline synthesis: synthesis of reserpine

PA Wender, JM Schaus, AW White

Index: Wender, P. A.; Schaus, J. M.; White, A. W. Journal of the American Chemical Society, 1980 , vol. 102, # 19 p. 6157 - 6159

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Citation Number: 69

Abstract

Rauwolfia serpentina Benth. was first reported in 1952 by Schlittler et al., 3 and its structure and stereochemistry4 were established soon thereafter through the elegant investigations of the groups of Schlittler, van Tamelen, Weisenborn, and Wenkert. 5 Hardly a year after these reports became public, Woodward and co-workers6 reported the first synthesis of this pentacyclic indole alkaloid. Following a hiatus of over 20 years, a second synthesis of ...