Hydantoin bioisosteres. In vivo active spiro hydroxy acetic acid aldose reductase inhibitors

CA Lipinski, CE Aldinger, TA Beyer…

Index: Lipinski, Christopher A.; Aldinger, Charles E.; Beyer, Thomas A.; Bordner, Jon; Burdi, Douglas F.; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 12 p. 2169 - 2177

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Citation Number: 29

Abstract

Previous studies from these laboratories have described the excellent in vitro and in vivo activity of spirohydantoin aldose reductase inhibitors (ARIs).'Clinical trials with the spirohydantoin sorbinil suggested efficacy" but were terminated because of a low incidence of side effects similar to those of the hydantoin anticonvulsant dilantix~.~ Because both drugs are hydantoins and have qualitatively similar side effects, we decided either to ...