Synthesis and antifertility activity of zoapatanol analogs

…, E Chin, C Smith, R Chen, D Rowand…

Index: Kanojia, Ramesh M.; Chin, Eva; Smith, Carol; Chen, Robert; Rowand, Deborah; et al. Journal of Medicinal Chemistry, 1985 , vol. 28, # 6 p. 796 - 803

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Citation Number: 23

Abstract

The synthesis of and guinea pig contragestational screening data for several oxepane and 3, 8-dioxabicyclo [3.2. lloctane analogues of zoapatanol (1) are described and their structure- activity relationships discussed. Conversion of the 5-keto group on the nonenyl side chain of 1 into a hydroxyl function enhanced the potency. Further significant enhancement in the potency was realized with the transformation of several oxepanes into the 3, 8- ...