Discrimination of β??Ketoesters by Ruthenium (II)–Binap??Catalyzed Asymmetric Hydrogenation

R Kramer, R Brückner

Index: Kramer, Rainer; Brueckner, Reinhard Angewandte Chemie - International Edition, 2007 , vol. 46, # 34 p. 6537 - 6541

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Citation Number: 24

Abstract

Since the pioneering work of Noyori and co-workers,[1] RuII complexes of enantiomerically pure atropisomers of 2, 2'-bis (diphenylphosphanyl)-1, 1'-binaphthyl(binap) have become the standard catalysts for the asymmetric hydrogenation (AH) of β-ketoesters 2 (Scheme 1).[2] β-Hydroxyesters 1 or their enantiomers ent-1 are formed in excellent yields and with rigorously controlled and unambiguously predictable absolute configurations.[3] Such ...

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