Synthesis

Synthesis of new thieno [b] azepinediones from α-methylene ketones

E Migianu, G Kirsch

Index: Migianu, Evelyne; Kirsch, Gilbert Synthesis, 2002 , # 8 p. 1096 - 1100

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Citation Number: 38

Abstract

In 1991, Kunick [4] described for the first time the synthesis of benzoazepinediones 5 from alkyl 2-aminobenzoates 2 (Scheme [1] ). Diesters 3 were prepared by the reaction of amines 2 with a 3-chlorocarbonylpropionic acid alkyl ester. The Dieckmann reaction from 3 using potassium hydride furnished compounds 4. Heating 4 in wet dimethyl sulfoxide yielded benzoazepinediones 5. ... To our knowledge, Kunick's report [4] is the only reference available in the literature ...