Synthesis

Synthesis of substituted pyridines and quinolines

MD Hill, M Movassaghi

Index: Hill, Matthew D.; Movassaghi, Mohammad Synthesis, 2007 , # 7 p. 1115 - 1119

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Citation Number: 10

Abstract

Abstract A variety of N-vinyl and N-aryl amides were converted to the corresponding pyridine and quinoline derivatives, respectively. Amide activation and nucleophilic addition of copper (I)(trimethylsilyl) acetylide efficiently provided the desired alkynyl imines. Ruthenium- catalyzed protodesilylation and cycloisomerization of these imines gave the corresponding azaheterocycles.