(Imidazo [1, 2-a] pyrimidin-2-yl) phenylmethanones and related compounds as potential nonsedative anxiolytics

S Clements-Jewery, G Danswan…

Index: Clements-Jewery, Stephen; Danswan, Geoffrey; Gardner, Colin R.; Matharu, Saroop S.; Murdoch, Robert; et al. Journal of Medicinal Chemistry, 1988 , vol. 31, # 6 p. 1220 - 1226

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Citation Number: 44

Abstract

OLiterat~ re~~ mp 147-148" C. bLiterature3a mp 263-265" C.'I= activity> 10 wM. With ClCH, COCH, CO, Et. eliteraturea mp 84-85" C. dihydroimidazo [1, 2-a] quinoxaline-2-carboxylate (la)? was found to have an ICbo value of 175 nM compared with 6 nM for that of nitrazepam. This prompted us to screen a large number of heterocyclic esters which we had previously prepared2* J'during the course of the antiallergy program for which la had been ...