Synthesis and biological activity of some very hydrophobic superagonist analogs of luteinizing hormone-releasing hormone

…, RA Simpson, BL Horner, GH Jones…

Index: Nestor Jr.; Ho; Simpson; Horner; Jones; McRae; Vickery Journal of Medicinal Chemistry, 1982 , vol. 25, # 7 p. 795 - 801

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Citation Number: 148

Abstract

The effect of increased hydrophobicity at position 6 of luteinizing hormone-releasing hormone (LH-RH) has been investigated by the incorporation of a series of 15 very hydrophobic, unnatural D-amino acids at this position. The unnatural amino acids studied can be considered analogues of phenylalanine with carbocyclic aromatic side chains consisting of substituted phenyl (eg, 2, 4, 6-trimethylphenyl, p-biphenyl) or polycyclic ...