Quinoline-and 1, 8-naphthyridine-3-carboxylic acids using a self-catalyzed Friedländer approach
B Nammalwar, M Murie, C Fortenberry, RA Bunce
Index: Nammalwar, Baskar; Murie, Maeghan; Fortenberry, Chelsea; Bunce, Richard A. Tetrahedron Letters, 2014 , vol. 55, # 20 p. 3181 - 3183
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Abstract
Abstract One-step syntheses of 2-alkyl-and 2, 4-dialkyl-substituted quinoline-3-carboxylic acids and 1, 8-naphthyridine-3-carboxylic acids are reported using a catalyst-free Friedländer reaction. The reaction is carried out in one step by simple heating of 2- aminobenzaldehyde, 2-amino-5-chlorobenzaldehyde, 2-aminonicotinaldehyde, or 2- aminoacetophenone with a β-ketoester in toluene or xylene for 24 h. Under these ...
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