Bioorganic & medicinal chemistry letters

Synthesis of new 3-arylisoquinolinamines: effect on topoisomerase I inhibition and cytotoxicity

WJ Cho, SY Min, TN Le, TS Kim

Index: Cho, Won-Jea; Min, Sun Young; Le, Thanh Nguyen; Kim, Tae Sung Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 24 p. 4451 - 4454

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Citation Number: 42

Abstract

To investigate the structure–activity relationships of 3-arylisoquinolines, diverse substituted 3-aryisoquinolinamines were synthesized and tested in vitro antitumor activity against four tumor cell lines. Some of the compounds showed potent topoisomerase I inhibitory activity. Docking study of 7d with topoisomerase I–DNA complex was also performed.