Synthetic inhibitors of cytochrome P-450 2A6: inhibitory activity, difference spectra, mechanism of inhibition, and protein cocrystallization
JK Yano, TT Denton, MA Cerny, X Zhang…
Index: Yano, Jason K.; Denton, Travis T.; Cerny, Matthew A.; Zhang, Xiaodong; Johnson, Eric F.; Cashman, John R. Journal of Medicinal Chemistry, 2006 , vol. 49, # 24 p. 6987 - 7001
Full Text: HTML
Citation Number: 93
Abstract
A series of 3-heteroaromatic analogues of nicotine were synthesized to delineate structural and mechanistic requirements for selectively inhibiting human cytochrome P450 (CYP) 2A6. Thiophene, substituted thiophene, furan, substituted furan, acetylene, imidazole, substituted imidazole, thiazole, pyrazole, substituted pyrazole, and aliphatic and isoxazol moieties were used to replace the N-methylpyrrolidine ring of nicotine. A number of potent inhibitors ...
Related Articles:
Synthesis of 5-pyridyl-2-furaldehydes via palladium-catalyzed cross-coupling with triorganozincates
[Gauthier Jr., Donald R.; Szumigala Jr., Ronald H.; Dormer, Peter G.; Armstrong III, Joseph D.; Volante; Reider, Paul J. Organic Letters, 2002 , vol. 4, # 3 p. 375 - 378]
A practical one-pot synthesis of 5-aryl-2-furaldehydes
[McClure; Roschangar; Hodson; Millar; Osterhout Synthesis, 2001 , # 11 p. 1681 - 1685]
[Bumagin; Veselov; Belov Chemistry of Heterocyclic Compounds, 2014 , vol. 50, # 1 p. 19 - 25 Khim. Geterotsikl. Soedin., 2014 , vol. 50, # 1 p. 24 - 31,7]
A practical one-pot synthesis of 5-aryl-2-furaldehydes
[McClure; Roschangar; Hodson; Millar; Osterhout Synthesis, 2001 , # 11 p. 1681 - 1685]
Synthesis of 5-pyridyl-2-furaldehydes via palladium-catalyzed cross-coupling with triorganozincates
[Gauthier Jr., Donald R.; Szumigala Jr., Ronald H.; Dormer, Peter G.; Armstrong III, Joseph D.; Volante; Reider, Paul J. Organic Letters, 2002 , vol. 4, # 3 p. 375 - 378]