Tricyclic pyrazoles. 3. Synthesis, biological evaluation, and molecular modeling of analogues of the cannabinoid antagonist 8-chloro-1-(2', 4'-dichlorophenyl)-N- …

G Murineddu, S Ruiu, G Loriga, I Manca…

Index: Murineddu, Gabriele; Ruiu, Stefania; Loriga, Giovanni; Manca, Ilaria; Lazzari, Paolo; Reali, Roberta; Pani, Luca; Toma, Lucio; Pinna, Gerard A. Journal of Medicinal Chemistry, 2005 , vol. 48, # 23 p. 7351 - 7362

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Citation Number: 41

Abstract

A series of analogues of 8-chloro-1-(2', 4'-dichlorophenyl)-N-piperidin-1-yl-1, 4, 5, 6- tetrahydrobenzo [6, 7] cyclohepta [1, 2-c] pyrazole-3-carboxamide 4a (NESS 0327)(Ruiu, S.; Pinna, GA; Marchese, G.; Mussinu, JM; Saba, P.; Tambaro, S.; Casti, P.; Vargiu, R.; Pani, L. Synthesis and Characterization of NESS 0327: A Novel Putative Antagonist of CB1 Cannabinoid Receptor. J. Pharmacol. Exp. Ther. 2003, 306, 363-370) was synthesized ...