Iron (II) triflate as a catalyst for the synthesis of indoles by intramolecular C− H amination
J Bonnamour, C Bolm
Index: Bonnamour, Julien; Bolm, Carsten Organic Letters, 2011 , vol. 13, # 8 p. 2012 - 2014
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Citation Number: 70
Abstract
As in other iron catalyses, the solvent played a major role in this reaction. Various solvents were screened, and the results are summarized in Table 1. Reactions performed (with 30 mol % of iron triflate at 80 °C) in DMF, acetonitrile, or protic polar solvents such as water and ethanol gave no product (entries 1−4). In hexane, toluene, and xylene (entries 5−7) as well as other solvents of low polarity, the yields were moderate to good (up to 58% for hexane). Ethers such as ...
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