Tetrahedron letters

Cyclic chlorophosphites as scaffolds for the one-pot synthesis of α-aminophosphonates under solvent-free conditions

KCK Swamy, S Kumaraswamy, KS Kumar, C Muthiah

Index: Swamy, K. C. Kumara; Kumaraswamy, Sudha; Kumar, K. Senthil; Muthiah Tetrahedron Letters, 2005 , vol. 46, # 19 p. 3347 - 3351

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Citation Number: 67

Abstract

New α-aminophosphonates of the type (OCH2CMe2CH2O) P (O) CH (NHCO2R)(R′)[,, and] have been synthesized in high yields by a three-component reaction using (OCH2CMe2CH2O) PCl (), benzamide (or urethane or benzyl carbamate), and an aldehyde without using any catalyst under solvent-free conditions. This route can be readily adapted for bis-aminophosphonates as well as optically active binaphthoxy α-aminophosphonates; ...