Synthesis of new pyridine intermediates as precursors for the elaboration of streptonigrin analogues by the metalation??cross??coupling strategy

…, A Godard, F Marsais, G Quéguiner

Index: Pomel; Rovera; Godard; Marsais; Queguiner Journal of Heterocyclic Chemistry, 1996 , vol. 33, # 6 p. 1995 - 2005

Full Text: HTML

Citation Number: 21

Abstract

2000 V. Pomel, JC Rovera, A. Godard, F. Marsais and G. Quéguiner Vol. 33 Conclusion. Our strategy for the synthesis of biologically active streptonigrin and its analogues requires the preparation of suitably substituted pyridines bearing more specially a carbonylated function at C-6. It was accomplished effi- ciently by oxidation of a vinylpyridine obtained by a Stille cross-coupling reaction. The synthesis of strepto- nigrin or its potentially active analogues is currently ...