A 4'-C-ethynyl-2', 3'-dideoxynucleoside analogue highlights the role of the 3'-OH in anti-HIV active 4'-C-ethynyl-2'-deoxy nucleosides

…, C George, SG Sarafinanos, VE Marquez

Index: Siddiqui, Maqbool A.; Hughes, Stephen H.; Boyer, Paul L.; Mitsuya, Hiroaki; Van, Que N.; George, Clifford; Sarafinanos, Stefan G.; Marquez, Victor E. Journal of Medicinal Chemistry, 2004 , vol. 47, # 21 p. 5041 - 5048

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Citation Number: 42

Abstract

4'-C-Ethynyl-2'-deoxynucleosides belong to a novel class of nucleoside analogues endowed with potent activity against a wide spectrum of HIV viruses, including a variety of resistant clones. Although favorable selectivity indices were reported for several of these analogues, some concern still exists regarding the 3'-OH group and its role in cellular toxicity. To address this problem, we removed the 3'-OH group from 4'-C-ethynyl-2'- ...

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