One-pot synthesis of benzoquinoline and coumarin derivatives using Meldrum's acid in three-component reactions

XM Wang, HL Ye, ZJ Qaun, XC Wang

Index: Wang, Xue-Mei; Ye, He-Lin; Qaun, Zheng-Jun; Wang, Xi-Cun Research on Chemical Intermediates, 2013 , vol. 39, # 6 p. 2357 - 2367

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Citation Number: 7

Abstract

Abstract A series of 1-aryl-1, 2-dihydrobenzo [f] quinolin-3 (4 H)-one derivatives and 4-aryl-7, 7-dimethyl-5-oxo-3, 4, 5, 6, 7, 8-hexahydrocoumarin derivatives have been synthesized by one-pot multicomponent reaction of Meldrum's acid with benzaldehyde, naphthalene-2- amine, or cyclohexanedione in PEG-400. The method has the advantages of mild reaction conditions, good yields, and easy processing, and is environmentally benign.