Isomeric phenylthioimidazo [1, 2-a] pyridines as anthelmintics

…, RA Reamer, G Wilks, JE Taylor, G Olson

Index: Bochis; Olen; Fisher; Reamer; Wilks; Taylor; Olson Journal of Medicinal Chemistry, 1981 , vol. 24, # 12 p. 1483 - 1487

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Citation Number: 31

Abstract

A series of isomeric imidazo [1, 2-a] pyridine-2-carbamates was prepared for testing as anthelmintics. The analogues were synthesized by reacting the appropriate 2-aminopyridine and methyl chloroacetylcarbamate. Steric hindrance in the 2, 6-disubstituted derivative resulted in the formation of the isomeric 3-substituted analogue as the major product. Carbn- 13 Nh4R proved useful in the structural assignments in this series. None of the analogues ...