Tetrahedron

Alkylation de quelques composés carbonylés par des groupes tertiaires. Utilisation de la réaction de friedel-crafts dans la synthèse d'ésters

C Lion, JE Dubois

Index: Lion, Claude; Dubois, Jacques-Emile Tetrahedron, 1981 , vol. 37, p. 319 - 323

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Abstract

t-Alkylation of carboxylic esters via their ketene alkyl trimethylsilyl acetals by the Friedal- Crafts reaction allows the synthesis of new highly hindered compounds. A new route using sodium amide in dimethoxyethane, for the preparation of trimethylsilylenol ethers of ketones, is described. The α-t-butylation of these compounds permits the synthesis of new crowded pentasubstituted ketones. The limits as well as the performance of the method have been ...