Synthesis

Synthesis and Characterization of New Cα, α-Disubstituted (Diarylaminomethyl)-phosphonates

HJ Cristau, JM Lambert, JL Pirat

Index: Cristau, Henri-Jean; Lambert, Jean-Marc; Pirat, Jean-Luc Synthesis, 1998 , # 8 p. 1167 - 1170

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Citation Number: 6

Abstract

Abstract: A convenient and efficient three-step procedure for the preparation of N-protected or unprotected Cα, α-disubstituted (diarylaminomethyl) phosphonates 1 is reported. This method allows diversification of the substituents on the carbon in the α-position to the phosphorus, as well as the protective group on the amine and the phosphonate ester group. Key words: Cα, α-disubstituted (diarylaminomethyl) phosphonates, Arbuzov reaction, ...