Bicyclic Peroxides and Perorthoesters with 1, 2, 4??Trioxane Structures

AG Griesbeck, D Blunk, TT El??Idreesy…

Index: Griesbeck, Axel G.; Blunk, Dirk; El-Idreesy, Tamer T.; Raabe, Angela Angewandte Chemie - International Edition, 2007 , vol. 46, # 46 p. 8883 - 8886

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Citation Number: 31

Abstract

The search for new compounds active against malaria has led to an increasing demand for the synthesis of new cyclic organic peroxides.[1] The naturally occurring sesquiterpene lactone peroxide artemisinin (quinhaosu), which contains a 1, 2, 4-trioxane subunit, serves as the natural active principle and model compound.[2] However, the most aggressive parasite, Plasmodium falciparum, is showing first resistance effects to artemisinin and its ...