Tetrahedron

Aminoarenethiolato-copper (I) as (pre-) catalyst for the synthesis of diaryl ethers from aryl bromides and sequential C–O/C–S and C–N/C–S cross coupling reactions

E Sperotto, GPM van Klink, JG de Vries, G van Koten

Index: Sperotto, Elena; Van Klink, Gerard P.M.; De Vries, Johannes G.; Van Koten, Gerard Tetrahedron, 2010 , vol. 66, # 46 p. 9009 - 9020

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Citation Number: 33

Abstract

A small library of 2-aminoarenethiolato-copper (I)(CuSAr) complexes was tested as (pre-) catalysts in the arylation reaction of phenols with aryl bromides. These copper (I)(pre-) catalysts are thermally stable, soluble in common organic solvents, and allow reactions of 6 h at 160° C with low catalyst loadings of 2.5 mol%. Among the (pre-) catalysts screened, 2- [(dimethylamino) methyl] benzenethiolato-copper (I)(1c) led to the best results and ...