Double Gold??Catalysed Annulation of Indoles by Enynones

…, AJ Hennessy, BI Andrews, DR Carbery

Index: Heffernan, Stephen J.; Tellam, James P.; Queru, Marine E.; Silvanus, Andrew C.; Benito, David; Mahon, Mary F.; Hennessy, Alan J.; Andrews, Benjamin I.; Carbery, David R. Advanced Synthesis and Catalysis, 2013 , vol. 355, # 6 p. 1149 - 1159

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Citation Number: 14

Abstract

Abstract The gold-catalysed double functionalisation of indoles is presented. Enynones are used to annulate indoles via a double sodium tetrachloroaurate-catalysed process involving a mixture of C [BOND] H activation and alkyne activation modes of promotion. Good yields for the formation of medicinally relevant [6, 5, 7]-tricyclic indoles are realised.