Rational design of 4-[(methylsulfonyl) amino] benzamides as class III antiarrhythmic agents

…, DD Davey, TM Argentieri, RJ DeVita…

Index: Lumma, William C.; Wohl, Ronald A.; Davey, David D.; Argentieri, Thomas M.; DeVita, Robert J.; et al. Journal of Medicinal Chemistry, 1987 , vol. 30, # 5 p. 755 - 758

Full Text: HTML

Citation Number: 67

Abstract

Class I11 antiarrhythmic agents' such as bretylium, amiodarone, and clofilium are thought to exert their primary antiarrhythmic effects by prolonging action potential duration (APD) and thereby increasing refractoriness with little or no effect on conduction. Of these only clofilium can be regarded as a selective class I11 agent. Clearly, there is a need for additional safe and efficacious agents acting