Ionization constants of the drugs amiridin and tacrine and their analogs

SB Goncharenko, MM Kaganskii, YN Portnov…

Index: Goncharenko, S. B.; Kaganskii, M.M.; Portnov, Yu. N.; Granik, V. G. Pharmaceutical Chemistry Journal, 1992 , vol. 26, # 9-10 p. 769 - 772 Khimiko-Farmatsevticheskii Zhurnal, 1992 , vol. 26, # 9-10 p. 83 - 85

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Abstract

The role of ionization in the appearance of biological activity in different classes of organic compounds is quite significant: for example, ionization can facilitate the appearance of selectivity of action of biologically active compounds, substantially affect their adsorption on the receptor surface, the permeability through the biological membranes, etcl [i]. So it is quite important to know the degree of ionization of biologically active compounds in studying ...