Synthesis of 2??hydroxy??2??phenylethylamino derivatives as potential α??adrenergic blocking agents
M Alvarez, R Granados, R Lavilla…
Index: Alvarez; Granados; Lavilla; Salas Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 3 p. 745 - 750
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Abstract
Abstract The synthesis of N, N'-bis [6-(2-hydroxy-2-phenylethylamino) hexyl] cystamines 4, and N-(2-hydroxy-2-phenylethyl)-1, 6-hexanediamines 6 are described. Compounds 4 were obtained by condensation of the requisite epoxide 2 with 3-(6-aminohexyl)-1, 3-thiazolidine followed by dimerization with opening of the thiazolidine ring. A similar method was used for the preparation of compounds 6. In order to prepare 4j (N, N'-bis {6-[2-hydroxy-2 (3, 4- ...
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