Novel class of benzoic acid ester derivatives as potent PDE4 inhibitors for inhaled administration in the treatment of respiratory diseases

E Armani, G Amari, A Rizzi, RD Fanti…

Index: Journal of Medicinal Chemistry, , vol. 57, # 3 p. 793 - 816

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Citation Number: 12

Abstract

... Journal of ... J. Med. Chem. , 2014, 57 (3), pp 793–816. DOI: 10.1021/jm401549m. Publication Date (Web): January 8, 2014. Copyright © 2014 American Chemical Society. ... Our medicinal chemistry strategy was initially based on the analysis of the PDE4 catalytic binding pocket. ...