Synthesis and xanthine oxidase inhibitory activity of 7-methyl-2-(phenoxymethyl)-5H-[1, 3, 4] thiadiazolo [3, 2-a] pyrimidin-5-one derivatives

…, SA Khanum, JNNS Chandra, F Ayisha, S Balaji…

Index: Sathisha; Khanum, Shaukath A.; Chandra, J.N. Narendra Sharath; Ayisha; Balaji; Marathe, Gopal K.; Gopal, Shubha; Rangappa Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 1 p. 211 - 220

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Citation Number: 27

Abstract

An elevated level of blood uric acid (hyperuricemia) is the underlying cause of gout. Xanthine oxidase is the key enzyme that catalyzes the oxidation of hypoxanthine to xanthine and then to uric acid. Allopurinol, a widely used xanthine oxidase inhibitor is the most commonly used drug to treat gout. However, a small but significant portion of the population suffers from adverse effects of allopurinol that includes gastrointestinal upset, skin rashes ...