A Practical Synthetic Method of O-(2-(Pyrazol-1-yl) pyridin-5-yl) methylhydroxylamine as a Component of Modithromycin

…, T Hakogi, N Umesako, Y Yokota, T Ueki

Index: Shimizu, Sumio; Hakogi, Toshikazu; Umesako, Naomi; Yokota, Yutaka; Ueki, Tatsuo Organic Process Research and Development, 2012 , vol. 16, # 2 p. 220 - 224

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Abstract

Shanghai Office, Shionogi & Co., Ltd., 318A, 3F, Building A, Far East International Plaza, No. 319, Xianxia Road, Shanghai 200051, China. ... Discovery Research Laboratories, Shionogi & Co., Ltd., 12-4, Sagisu 5-chome, Fukushima-ku, Osaka 553-0002, Japan. ... A practical synthesis of O-(2-(pyrazol-1-yl)pyridin-5-yl)methylhydroxylamine was achieved from the inexpensive raw materials, 2-chloro-5-chloromethylpyridine, pyrazole, and acetone oxime, using common ...