Tetrahedron

A simple and efficient synthesis of pyrazoles in water

J Wen, Y Fu, RY Zhang, J Zhang, SY Chen, XQ Yu

Index: Wen, Jun; Fu, Yun; Zhang, Ruo-Yi; Zhang, Ji; Chen, Shan-Yong; Yu, Xiao-Qi Tetrahedron, 2011 , vol. 67, # 49 p. 9618 - 9621

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Citation Number: 25

Abstract

A simple, highly efficient, and environmentally friendly method for the synthesis of substituted 1H-pyrazoles by one-pot condensation reaction of α, β-unsaturated carbonyl compounds with tosyl hydrazide in water was developed. The reaction system exhibited tolerance with various functional groups, Aromatic moiety with both electron-rich and electron-deficient substituents could give desired products in good to excellent yields.