Synthesis of 5-aryl-2H-tetrazoles, 5-aryl-2H-tetrazole-2-acetic acids, and [(4-phenyl-5-aryl-4H-1, 2, 4-triazol-3-yl) thio] acetic acids as possible superoxide scavengers …

…, DA Wasdahl, AC Wolfson, VI Stenberg

Index: Maxwell, James R.; Wasdahl, Dan A.; Wolfson, Alan C.; Stenberg, Virgil I. Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1565 - 1570

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Citation Number: 96

Abstract

A series of B-aryl-W-tetrazoles, 5-aryl-W-tetrazole-2-acetic acids, and [(4-phenyl-5-aryl-4H-1, 2, 4-triazol-3-yl) thio] acetic acids were synthesized and tested in vitro for superoxide scavenging activity, in vivo in the carrageenan-induced rat paw edema assay, and in the reverse passive Arthus reaction. The hydroxy-substituted compounds were effective as in vitro scavengers of superoxide but were not effective as in vivo antiinflammatory agents.