Synthesis and Antibacterial Activity of Bis [2-amino-4-phenyl-5-thiazolyl] Disulfides

HL Siddiqui, M Zia-ur-Rehman, N Ahmad…

Index: Siddiqui, Hamid Latif; Zia-Ur-Rehman, Muhammad; Ahmad, Naveed; Weaver, George William; Lucas, Paul David Chemical and Pharmaceutical Bulletin, 2007 , vol. 55, # 7 p. 1014 - 1017

Full Text: HTML

Citation Number: 25

Abstract

Different dimeric disulfides, having the basic skeleton of bis [2-amino-4-phenyl-5-thiazolyl] disulfides were synthesized in a straightforward manner from acetophenones. 2-Amino-4- phenyl-1, 3-thiazoles were prepared by the reaction of thiourea with substituted acetophenones in the presence of iodine which were then converted to the title compounds. All the compounds were subjected to preliminary evaluation for their biological activity ...