Synthesis of halogen-substituted 3-deazaadenosine and 3-deazaguanosine analogues as potential antitumor/antiviral agents

…, DE Mozdziesz, TS Lin† 1, GE Dutschman…

Index: Liu; Luo; Mozdziesz; Lin; Dutschman; Gullen; Cheng; Sartorelli Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1975 - 2000

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Citation Number: 20

Abstract

Various 2-halogen-substituted analogues (38, 39, 43 and 44), 3-halogen-substituted analogues (51 and 52), and 2′, 3′-dihalogen-substituted analogues (57–60) of 3- deazaadenosine and 3-halogen-substituted analogues (61 and 62) of 3-deazaguanosine have been synthesized as potential anticancer and/or antiviral agents. Among these compounds, 3-deaza-3-bromoguanosine (62) showed significant cytotoxicity against ...