New polyethyleneglycol-functionalized texaphyrins: synthesis and in vitro biological studies
…, M Sirisawad, L Naumovski, D Magda, JL Sessler
Index: Wei, Wen-Hao; Wang, Zhong; Mizuno, Toshihisa; Cortez, Cecilia; Fu, Lei; Sirisawad, Mint; Naumovski, Louie; Magda, Darren; Sessler, Jonathan L. Dalton Transactions, 2006 , # 16 p. 1934 - 1942
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Citation Number: 18
Abstract
The synthesis of four new analogues of motexafin gadolinium (MGd), a gadolinium (III) texaphyrin complex in clinical trials for its anticancer properties, is described. These new derivatives contain either 1, 2-diaminobenzene or 2, 3-diaminonaphthalene subunits as the source of the imine nitrogens and bear multiple 2-[2-(2-methoxyethoxy) ethoxy] ethoxy (PEG) groups, on either meso aryl or beta-pyrrolic substituents, to increase their water ...
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