Tetrahedron letters

A short and efficient synthetic protocol for the synthesis of 5-substituted-4, 6-dioxo-pyrrolo [2, 3-d] pyrimidines

NM Sekhar, PVR Acharyulu, Y Anjaneyulu

Index: Sekhar; Acharyulu, Palle V.R.; Anjaneyulu, Yerramilli Tetrahedron Letters, 2011 , vol. 52, # 32 p. 4140 - 4144

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Citation Number: 8

Abstract

Abstract A short and efficient synthesis for 5-substituted-4, 6-dioxo-pyrrolo [2, 3-d] pyrimidines has been developed by the cyclocondensation of α, α-dibromoaldehydes with 2, 4-diamino-6-hydroxypyrimidine under mild basic conditions in good yields. Application of this protocol has been demonstrated in the synthesis of a metabolite of Pemetrexed disodium, a novel multi-targeted antifolate.