Tetrahedron letters

A new facile procedure for the preparation of pyrrolo [2, 1-c][1, 4] benzodiazepines: Synthesis of the antibiotic DC-81 and its thio analogue

A Kamal, BSP Reddy, BSN Reddy

Index: Kamal, Ahmed; Reddy, B. S. Praveen; Reddy, B. S. Narayan Tetrahedron Letters, 1996 , vol. 37, # 13 p. 2281 - 2284

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Citation Number: 32

Abstract

An efficient synthesis of the imine form of the pyrrolo [2, 1-c][1, 4] benzodiazepine ring system based on a new reductive cyclization procedure is described. The naturally occuring antibiotic DC-81 (5c) and its 5-thio analogue (7c) have also been synthesized to illustrate the usefulness of this methodology.