Chemo-enzymatic synthesis of functionalized oligomers of N-acetyllactosamine glycan derivatives and their immobilization on biomaterial surfaces

…, T Anders, M Henze, H Keul, M Möller, L Elling

Index: Adamiak, Kathrin; Anders, Thorsten; Henze, Manja; Keul, Helmut; Moeller, Martin; Elling, Lothar Journal of Molecular Catalysis B: Enzymatic, 2012 , vol. 84, p. 108 - 114

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Citation Number: 10

Abstract

Poly-N-acetyllactosamines (poly-LacNAc,[− 3Gal (β1–4) GlcNAc (β1−] n) are terminal glycan structures present in glycoproteins and glycolipids. Their biological functions as ligands for galectins and as carriers of glycan epitopes are well documented. In the present paper we have characterized six novel functionalized β-d-GlcNAc derivatives, including aglyca of varying hydrophobicity and molecular weight, as substrates for recombinant human β1, 4 ...