Tetrahedron Letters

Enhanced trans diastereoselection in the allylation of cyclic chiral N-acyliminium ions. Synthesis of hydroxylated indolizidines

CF Klitzke, RA Pilli

Index: Klitzke, Clecio Fernando; Pilli, Ronaldo Aloise Tetrahedron Letters, 2001 , vol. 42, # 33 p. 5605 - 5608

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Citation Number: 75

Abstract

Polyhydroxylated indolizidine alkaloids are sugar mimics which inhibit glycosidases with promising potential as drugs against viruses, cancers and diabetes. 1 A large number of representative structures were isolated from natural sources and the synthesis of the corresponding stereoisomers and analogues is actively pursued particularly for structure–activity studies. 1., 2., and A variety of methods have been reported for the synthesis of indolizidine alkaloids and ...