Tachykinin NK-1 receptor probed with constrained analogues of substance P

S Sagan, H Josien, P Karoyan, A Brunissen…

Index: Sagan, Sandrine; Josien, Hubert; Karoyan, Philippe; Brunissen, Alie; Chassaing, Gerard; Lavielle, Solange Bioorganic and Medicinal Chemistry, 1996 , vol. 4, # 12 p. 2167 - 2178

Full Text: HTML

Citation Number: 23

Abstract

The action of rotameric probes introduced either in position 7 or 8 in the sequence of substance P (SP) was investigated, ie l-tetrahydroisoquinoleic acid (Tic), l-fluorenylglycine (Flg), l-diphenylalanine (Dip), the diastereoisomers of l-1-indanylglycine (Ing) and l-benz [ƒ] indanylglycine (Bfi), the Z-and E-isomers of dehydrophenylalanine and dehydronaphthylalanine (ΔZPhe, ΔEPhe, ΔZNal, ΔENal) and lo, o′- ...