Journal of the American Chemical Society

Mechanism and active site residues of GDP-fucose synthase

STB Lau, ME Tanner

Index: Lau, Stephen T. B.; Tanner, Martin E. Journal of the American Chemical Society, 2008 , vol. 130, # 51 p. 17593 - 17602

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Citation Number: 16

Abstract

l-Fucose, 6-deoxy-l-galactose, is a key component of many important glycoconjugates including the blood group antigens and the LewisX ligands. The biosynthesis of GDP-l- fucose begins with the action of a dehydratase that converts GDP-d-mannose into GDP-4- keto-6-deoxy-mannose. The enzyme GDP-fucose synthase, GFS,(also known as GDP-4- keto-6-deoxy-d-mannose epimerase/reductase, GMER) then converts GDP-4-keto-6- ...